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How to Build a GPT-3 for Science

Want to create an image of velociraptors working on a skyscraper, in the style of “Lunch Atop A Skyscraper” of 1932? Use DALL-E. Want to create an imaginary standup comedy show by Peter Thiel, Elon...

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Remote Startups Will Win the War for Top Talent

The ease and speed with which you can now buy nearly anything — truly, anything — online is often taken for granted: not just food, but cars, homes, blue-chip art, even a college education. In the past...

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Thinking Through CC0 and IP for NFT Communities

Welcome to Web3 Water Cooler, a moderated Slack chat about a trending topic in crypto. This week’s participants are Orca Protocol’s Chase Chapman, Austin Hurwitz of Venice Music, and IP lawyer Nuzayra...

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Jason Fried on Why He Doesn’t Do Planning or Politics at Work

Compared with many startups, 37signals cofounder Jason Fried’s views around workplace culture, structure, and strategy could be considered subversive. He’d call them “honest,” a word he uses often when...

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What Synthetic Embryos Can and Can’t Do, Now and in the Future

Magdalena Zernicka-Goetz is the Bren Professor of Biology and Biological Engineering at the California Institute of Technology and a Professor of Stem Cell Biology and Development at the University of...

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Grow or Die: A Framework for Turning Your Company Around Fast

This post originally ran here. Most great teams would agree, there’s nothing more powerful for executing on big ambitions than a clearly defined and well-communicated goal. But sometimes the stakes are...

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Research Twice, Build Once: How to Know Your Users as You Grow

Far too many products still fail because there’s simply no demand for them. How does that happen? Or, how do so many startups launch entire businesses without realizing users didn’t need their...

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Our Cities Have an API Problem. Startups Can Fix It.

“Cities are technological artifacts,” Kevin Kelly once wrote, “the largest technology we make.” What if we looked at America’s cities not metaphorically as tech, but literally as a technological...

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Did We Overeat on Software?

It’s been a little over a decade since Marc Andreesen famously declared that software was eating the world. He was right. Now, we’re in a new phase: There is powerful software everywhere we look, and...

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Why Applying Machine Learning to Biology is Hard – But Worth It

Jimmy Lin is CSO of Freenome, which is developing blood-based tests for early cancer detection, starting with colon cancer. He is a pioneer in developing computational approaches to extract insights...

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